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AFTER MACI
Benchmarks

What published cohorts achieved

A benchmark on this page is a description of what happened in a published cohort, at a timepoint, on an instrument. It is not a requirement, and it is not a target — the cohorts were selected, the measures have known distortions, and your surgeon and PT set your progression. Every figure keeps its caveats in the same card, on purpose.

Tracking your own numbers? My Record plots your flexion and KOOS-Pain entries against these cohorts.

Passive flexion · yours against what protocols state
yours ●   protocol milestone ▬
0°70°150°WK 0WK 24
These are the range figures published protocols state, at the weeks they state them — not measurements taken from patients. Nobody has published week-by-week flexion norms after this operation, so there is no cohort spread to plot you against, and being under or over a marker means neither failure nor licence to push. The two locations progress range differently, so only yours is drawn. 146.5° / 149.3° at ten years, by weight-bearing arm — the one measured flexion figure in this literature, and it sits a decade past the end of this chart.
KOOS · THE PROFILE SHAPE

Pain and daily function recover close to ceiling. Sport and quality of life do not. That shape — not any single number — is the finding worth carrying.

KOOS · Pain — 10 years
TIBIOFEMORAL
88.4 / 88.10–100, by arm
Randomized femoral condyle cohort, 6- vs 8-week weight-bearing arms · n = 31 knees at 10 years
Evidence strength 4 of 5
RCT · n = 35 pts / 37 knees · 10 yr follow-upE1

Selected cohort: trial entry excluded instability, malalignment beyond 5°, and BMI over 35. What a screened cohort achieved is not a floor for an unscreened knee.

KOOS · Sport/Rec — 10 years
TIBIOFEMORAL
78.0 / 76.80–100, by arm
Randomized femoral condyle cohort, 6- vs 8-week weight-bearing arms · n = 31 knees at 10 years
Evidence strength 4 of 5
RCT · n = 35 pts / 37 knees · 10 yr follow-upE1

Note the profile shape: pain and daily function recover close to ceiling; sport does not. That gap at ten years is the honest expectation, not a shortfall of this cohort.

KOOS · Quality of Life — 10 years
TIBIOFEMORAL
69.4 / 69.30–100, by arm
Randomized femoral condyle cohort, 6- vs 8-week weight-bearing arms · n = 31 knees at 10 years
Evidence strength 4 of 5
RCT · n = 35 pts / 37 knees · 10 yr follow-upE1

Quality-of-life near 69 at ten years — in a successful, selected cohort — is one of the most useful expectation-setting numbers on this site. Recovery that is real and durable still reads as a knee you know you have.

KOOS · Pain — ≥10 years
PATELLOFEMORAL
84.7 ± 120–100
Patellofemoral MACI prospective series (patella and trochlea) · n = 82
Evidence strength 2 of 5
Prospective case series · n = 82 · 11.9 yr mean follow-upE10

Gains were achieved by year two and held flat to ten-plus years. 35.4% of this cohort had a tibial tubercle osteotomy — published timelines and consensus tables excluded exactly those patients.

KOOS · Sport/Rec — ≥10 years
PATELLOFEMORAL
57.3 ± 30.10–100
Patellofemoral MACI prospective series (patella and trochlea) · n = 82
Evidence strength 2 of 5
Prospective case series · n = 82 · 11.9 yr mean follow-upE10

A standard deviation of ±30 means the average conceals enormous spread — individual outcomes ranged from near-ceiling to barely changed. Dispersion is the finding here, not the mean.

KOOS · Quality of Life — ≥10 years
PATELLOFEMORAL
58.6 ± 23.90–100
Patellofemoral MACI prospective series (patella and trochlea) · n = 82
Evidence strength 2 of 5
Prospective case series · n = 82 · 11.9 yr mean follow-upE10

Lower than the femoral condyle cohort's 69 — location itself predicted the sport and quality-of-life difference in the 10-year regression. Satisfaction in this cohort was still 90.2%.

KOOS · Pain — 2 years
MIXED COHORT
37.0 → 82.50–100
SUMMIT randomized trial, MACI arm, defects ≥3 cm² · n = 144 randomized
Evidence strength 4 of 5
RCT · n = 144 · 2 yr follow-upE7E8

Two-year outcomes, held through the five-year extension. Comparing an early post-operative score to a two-year figure tells you almost nothing yet — cohort curves are for orientation, not grading.

STRENGTH & SYMMETRY

Strength is the modifiable long-horizon variable — and the most commonly mismeasured. Symmetry against a detrained leg flatters both.

isokinetic-strength · knee extensor @45° flexion — 5 years
MIXED COHORT
reduced at all speeds (P < .05)
Cross-sectional isokinetic testing after ACI · n = 60
Evidence strength 2 of 5
Cross-sectional isokinetic study · n = 60 · 5 yr follow-upE14

The deficit is angle-specific — peak-torque testing missed it. The authors' own conclusion: early supervised rehabilitation is not sufficient to restore long-term knee strength.

Cross-sectional design with no pre-operative baseline; it shows where cohorts sit at five years, not a trajectory.

LSI · extensor, flexor, and hop tests — 10 years
TIBIOFEMORAL
99.1–103.8% across tests
Randomized femoral condyle cohort · n = 31 knees at 10 years
Evidence strength 4 of 5
RCT · n = 35 pts / 37 knees · 10 yr follow-upE1

The cohort's own authors stated that limb symmetry can overestimate knee function: if the uninvolved leg also detrained through months of altered loading, the ratio improves while absolute strength does not.

Absolute strength against a pre-operative baseline is more informative — which is why the Before page tells you to request one.

LSI · knee extensor — ≥10 years
PATELLOFEMORAL
89.0% (patella 91.4 / trochlea 86.7)
Patellofemoral MACI prospective series · n = 82
Evidence strength 2 of 5
Prospective case series · n = 82 · 11.9 yr mean follow-upE10

LSI can overestimate knee function — the ratio flatters when the comparison leg has detrained too, a limitation the literature that popularized the measure states itself.

The extensor asymmetry persisting past ten years, while flexors sit at 100%, is the same angle-specific quadriceps story the strength benchmark tells.

ACTIVITY & RETURN TO SPORT

The ranges here are wide because the underlying studies rarely defined “return”. A wide range is a statement about the evidence, not about your knee.

Tegner · activity level — 2 years
MIXED COHORT
2.97 → 4.09; 59% improved ≥1 point
Prospective MACI cohort, 83 tibiofemoral / 67 patellofemoral · n = 150
Evidence strength 3 of 5
Prospective cohort · n = 150 (83 TF / 67 PF) · 2 yr follow-upE16

The most honest activity dataset available: 85% were satisfied with recreational return, 66% with sport, and fewer than six in ten moved even one Tegner point. Satisfaction depends on what you are returning to.

return-to-sport — pooled across studies
MIXED COHORT
80.3% returned (CI 73.3–86.5)
Meta-analysis, athletes across cartilage restoration procedures · n = 52 studies / 2,387
Evidence strength 4 of 5
Systematic review + meta-analysis · n = 52 studies / 2,387E18

Pools procedures, sports, and levels; most component studies never defined what "return" meant. MACI's odds of returning at the same or greater level were favourable (OR 2.15) — in that same undefined sense.

return-to-sport — mean 39.9 weeks
MIXED COHORT
84.3% returned (CI 75.4–91.8)
Meta-analysis, professional athletes after cartilage restoration · n = 11 studies / 476
Evidence strength 4 of 5
Systematic review + meta-analysis · n = 11 studies / 476 · 39.9 wk mean follow-upE19

Under 4% of these athletes were female — the number simply has not been measured for women at this level, and that gap is reported here rather than smoothed over.

82% of the component studies omitted return-to-sport criteria entirely.

return-to-sport · pivoting sports — ~10–16 months
MIXED COHORT
33–96% returned; 26–67% at pre-injury level
Scoping review, pivoting-sport athletes after ACI · n = review; n not pooled
Evidence strength 1 of 5
Scoping reviewE20

The widest range of any procedure — because no standardized return criteria exist anywhere in this literature. A range that wide is a statement about the evidence, not about your knee.

What nobody knows about progression gates

No study in this literature used a criterion-based battery to decide when a patient progressed.

Which is awkward, because this site publishes gates. Progression was time-based in every study; the batteries that exist were validated in ACL reconstruction. The gates here are assembled from described protocols and surveyed practice, and say so where they are used.

From the register of what we don’t know: № 04